Formulation and Evaluation of Self Micro-Emulsifying drug delivery System of Carvedilol

The current work involves preparation and evaluation of self-micro emulsifying drug delivery system carvedilol, an nonselective betablocker alpha-1 blocker. Oral self micro-emulsifying Carvedilol were prepared by studying the solubility in different oils, surfactants co-surfactants formulations using mixtures surfactants, cosurfactants various proportions. Based on study, optimised carvedilol was Capryol 90 as oil phase tween 20 transcutol P surfactant co-surfactant, respectively. evaluated for stability, globule size vitro performance. To estimate content from excipients, final microemulsion performance a stability-indicating validated high-performance liquid chromatography method developed Inertsil ODS-3V (150 mm×4.6 mm, 5 μm) column. parametes like accuracy, linearity, precision (intraday interday) robustness. All validation parameters acceptable range. found to be specific accurate robust estimation its formulations.